Background science

Mimetic Peptide

Rusconi et al.

Circulation 2016

Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function – PubMed (nih.gov)

Miragoli et al.

Sci Transl Med 2018

Inhalation of peptide-loaded nanoparticles improves heart failure – PubMed (nih.gov)

Di Mauro et al.

Front Physiol 2021

Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome – PubMed (nih.gov)

Arina et al.

Shock 2022

Modulation of LTCC Pathways by a Melusin Mimetic Increases Ventricular Contractility During LPS-Induced Cardiomyopathy – PubMed (nih.gov)

microRNA

Modica et al.

Circulation 2021

Nano-miR-133a Replacement Therapy Blunts Pressure Overload-Induced Heart Failure – PubMed (nih.gov)

Delivery mode

Di Mauro et al.

Nanomedicine 2016

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs – PubMed (nih.gov)

Miragoli et al.

Sci Transl Med 2018

Inhalation of peptide-loaded nanoparticles improves heart failure – PubMed (nih.gov)

Modica et al.

Circulation 2021

Nano-miR-133a Replacement Therapy Blunts Pressure Overload-Induced Heart Failure – PubMed (nih.gov)

Quarta et al.

Pharmaceutics 2021

Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design – PubMed (nih.gov)

Quarta et al.

Journal of Drug Delivery Science and Technology 2022

Dry powder inhalation technology for heart targeting applied to calcium phosphate nanoparticles loaded with active substances – ScienceDirect