Background science
Mimetic Peptide
Rusconi et al.
Circulation 2016
Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function – PubMed (nih.gov)
Miragoli et al.
Sci Transl Med 2018
Inhalation of peptide-loaded nanoparticles improves heart failure – PubMed (nih.gov)
Di Mauro et al.
Front Physiol 2021
Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome – PubMed (nih.gov)
Arina et al.
Shock 2022
Modulation of LTCC Pathways by a Melusin Mimetic Increases Ventricular Contractility During LPS-Induced Cardiomyopathy – PubMed (nih.gov)
microRNA
Modica et al.
Circulation 2021
Nano-miR-133a Replacement Therapy Blunts Pressure Overload-Induced Heart Failure – PubMed (nih.gov)
Delivery mode
Di Mauro et al.
Nanomedicine 2016
Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs – PubMed (nih.gov)
Miragoli et al.
Sci Transl Med 2018
Inhalation of peptide-loaded nanoparticles improves heart failure – PubMed (nih.gov)
Modica et al.
Circulation 2021
Nano-miR-133a Replacement Therapy Blunts Pressure Overload-Induced Heart Failure – PubMed (nih.gov)
Quarta et al.
Pharmaceutics 2021
Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design – PubMed (nih.gov)
Quarta et al.
Journal of Drug Delivery Science and Technology 2022
Dry powder inhalation technology for heart targeting applied to calcium phosphate nanoparticles loaded with active substances – ScienceDirect